Informatics development: Challenges and solutions for MALDI mass spectrometry

Informatics development: challenges and solutions for MALDI mass spectrometry.

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been successfully applied to elucidating biological questions trough the analysis of proteins, peptides, and nucleic acids. Here, we review the different approaches for analyzing the data that is generated by MALDI-MS. The first step in the analysis is the processing of the raw data to find peaks that correspond to the...

Informatics for tandem mass spectrometry-based metabolomics

Metabolomics is a rapidly expanding field with applications in areas such as medicine, agriculture, or food safety. Tandem mass spectrometry (MS) is one of the main technologies that drives the field forward. Optionally coupled to a chromatographic element, MS can capture detailed snapshots of an organism’s metabolome. The resulting data sets are complex and difficult to analyse due to the mult...

Ion Formation in Maldi Mass Spectrometry

II. Experimental Parameters in MALDI-MS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 A. Laser Wavelength . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

MALDI Mass Spectrometry of Synthetic Polymers

This paper reviews the application of matrixassisted laser desorption/ionization mass spectrometry (MALDI-MS) to the analysis of synthetic polymers, and includes data obtained by Toyota CRDL. In MALDI-MS of synthetic polymers, the selection of a matrix and cationizing agent, as well as the sample preparation techniques, are very important to obtaining a successful spectrum. MALDI-MS makes it po...

Using AP-MALDI Ion Trap Mass Spectrometry